Comparison of empagliflozin and glimepiride as add-on to metformin in patients with type 2 diabetes: a 104-week randomised, active-controlled, double-blind, phase 3 trial

The Lancet: 16 June 2014 Background Metformin is the recommended first-line pharmacotherapy for patients with type 2 diabetes. There is no consensus on the optimum second-line pharmacotherapy. We compared the efficacy and safety of the sodium glucose cotransporter 2 inhibitor empagliflozin and the sulfonylurea glimepiride as add-on to metformin in patients with type 2 diabetes. Methods […]

Effects of Weight Loss, Weight Cycling, and Weight Loss Maintenance on Diabetes Incidence and Change in Cardiometabolic Traits in the Diabetes Prevention Program

Diabetes Care: July 14, 2014 OBJECTIVE This study examined specific measures of weight loss in relation to incident diabetes and improvement in cardiometabolic risk factors. RESEARCH DESIGN AND METHODS This prospective, observational study analyzed nine weight measures, characterizing baseline weight, short- versus long-term weight loss, short- versus long-term weight regain, and weight cycling, within the Diabetes Prevention Program […]

New Beginnings: A Discussion Guide for Living Well with Diabetes

CDC: 7/11/14 New Beginnings: A Discussion Guide for Living Well with Diabetes is an on-line resource that uses stories about African Americans with diabetes to help group leaders lead discussions about the emotional side of living with diabetes, and help people with diabetes identify family and social support needs and develop goal setting, positive coping and problem […]

National Trends in US Hospital Admissions for Hyperglycemia and Hypoglycemia Among Medicare Beneficiaries, 1999 to 2011

JAMA: July 2014 Importance  The increasing intensity of diabetes mellitus management over the past decade may have resulted in lower rates of hyperglycemic emergencies but higher rates of hospital admissions for hypoglycemia among older adults. Trends in these hospitalizations and subsequent outcomes are not known. Objective  To characterize changes in hyperglycemia and hypoglycemia hospitalization rates and subsequent mortality […]

Depression and Adherence to Lifestyle Changes in Type 2 Diabetes A Systematic Review

The Diabetes Educator” June 17, 2014 Abstract Purpose Depression affects millions of people worldwide and is prevalent among those with diabetes. The purpose of this review was to synthesize recent research on depression and adherence to dietary and physical activity recommendations in persons with type 2 diabetes (T2DM). Methods This systematic review is a subanalysis of an NIH-funded […]

Higher potency statins and the risk of new diabetes: multicentre, observational study of administrative databases

BMJ: d 29 May 2014 Abstract Objective To evaluate the incremental increase in new onset diabetes from higher potency statins compared with lower potency statins when used for secondary prevention. Design Eight population based cohort studies and a meta-analysis. Setting Six Canadian provinces and two international databases from the UK and US. Participants 136 966 patients aged ≥40 years newly treated […]

Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond

Diabetologia/ Springer: 8/1/14 During the past 7 years, genome-wide association studies have shed light on the contribution of common genomic variants to the genetic architecture of type 2 diabetes, obesity and related intermediate phenotypes. The discoveries have firmly established more than 175 genomic loci associated with these phenotypes. Despite the tight correlation between type 2 diabetes and […]

Contributors to Mortality in High-Risk Diabetic Patients in the Diabetes Heart Study

Diabetes Care: July 2, 2014 OBJECTIVE Not all individuals with type 2 diabetes and high coronary artery calcified plaque (CAC) experience the same risk for adverse outcomes. This study examined a subset of high-risk individuals based on CAC >1,000 mg (using a total mass score) and evaluated whether differences in a range of modifiable cardiovascular disease (CVD) […]

Breast-feeding and maternal risk of type 2 diabetes: a prospective study and meta-analysis

Springer/Diabetologia: July 2014 Aims/hypothesis We aimed to examine the association between breast-feeding and maternal risk of type 2 diabetes and to investigate whether this association is mediated by anthropometric and biochemical factors. Methods A case–cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study between 1994 and 2005 including 1,262 childbearing women […]

Effect of Patients’ Risks and Preferences on Health Gains With Plasma Glucose Level Lowering in Type 2 Diabetes Mellitus

JAMA: 6/30/14 Importance  Type 2 diabetes mellitus is common, and treatment to correct blood glucose levels is standard. However, treatment burden starts years before treatment benefits accrue. Because guidelines often ignore treatment burden, many patients with diabetes may be overtreated. Objective  To examine how treatment burden affects the benefits of intensive vs moderate glycemic control in patients with […]

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