Supporting self-management after attending a structured education programme: a qualitative longitudinal investigation of type 1 diabetes patients¿ experiences and views

biomedcentral.com: 8/14/12 Structured education programmes for patients with diabetes and other chronic conditions are being widely adopted. However, follow-up studies suggest that course graduates may struggle to sustain the self-care practices taught on their courses over time. This study explored the support needs of patients with type 1 diabetes after attending a structured education programme promoting […]

Outcomes with various drug eluting or bare metal stents in patients with diabetes mellitus: mixed treatment comparison analysis of 22 844 patient years of follow-up from randomised trials

bmj.com: August 10, 2012 To evaluate the efficacy and safety of currently used drug eluting stents compared with each other and compared with bare metal stents in patients with diabetes. Design Mixed treatment comparison meta-analysis. Data sources and study selection PubMed, Embase, and CENTRAL were searched for randomised clinical trials, until April 2012, of four durable polymer drug […]

Mortality Among Low-Income African Americans and Whites With Diabetes

Care.diabetesjournals.org: August 21, 2012 OBJECTIVE To estimate mortality rates and risk factors for mortality in a low–socioeconomic status (SES) population of African Americans and whites with diabetes. RESEARCH DESIGN AND METHODS We determined mortality among African Americans and whites aged 40–79 years with (n = 12,498) and without (n = 49,914) diabetes at entry into a cohort of participants recruited […]

Combating diabetes in the American Indian community

pbs.org: August 15, 2012. Nearly one in four U.S. teens has diabetes or pre-diabetes. The number of those affected has raced out of control, from 9.9 percent in 2000 to 23 percent in 2008, according to the June issue of Pediatrics. This news doesn’t bode well for kids throughout America, who are losing ground daily to the […]

Accelerating the Development of New Drugs and Diagnostics: Maximizing the Impact of the Cures Acceleration Network – Workshop Summary

Iom.edu: August 22, 2012. Advances in technologies and knowledge are creating new avenues for research and opportunities for the discovery and clinical development of innovative therapies and diagnostics. However, despite these opportunities, only a small fraction of investigational products are successfully developed into cures and therapies that can be accessed by patients. One response to the […]

The Value of Statistical Analysis Plans in Observational Research

Jama.jamanetwork: August 22/29, 2012 The increasing availability of electronic health data combined with federal investment has stimulated an expansion in observational clinical research.1 Observational studies can complement clinical trials and provide important information about comparative safety and effectiveness in populations not well studied in clinical trials. However, there are numerous examples in which the findings from observational […]

Drug safety assessment in clinical trials: methodological challenges and opportunities

Trialsjournal.com: August 20, 2012 Randomized controlled trials are the principal means of establishing the efficacy of drugs. However pre-marketing trials are limited in size and duration and exclude high-risk populations. They have limited statistical power to detect rare but potentially serious adverse events in real-world patients. We summarize the principal methodological challenges in the reporting, analysis […]

Diagnostic randomized controlled trials: the final frontier

Trialsjournal.com: August 16, 2012 Clinicians, patients, governments, third-party payers, and the public take for granted that diagnostic tests are accurate, safe and effective. However, we may be seriously misled if we are relying on robust study design to ensure accurate, safe, and effective diagnostic tests. Properly conducted, randomized controlled trials are the gold standard for assessing […]

Outcomes in Registered, Ongoing Randomized Controlled Trials of Patient Education

Plosone.org: 8/16/12 With the increasing prevalence of chronic noncommunicable diseases, patient education is becoming important to strengthen disease prevention and control. We aimed to systematically determine the extent to which registered, ongoing randomized controlled trials (RCTs) evaluated an educational intervention focus on patient-important outcomes (i.e., outcomes measuring patient health status and quality of life). Methods On […]

Association Between Longer Therapy With Thiazolidinediones and Risk of Bladder Cancer: A Cohort Study

Jnci.oxfordjournals.org: 8/9/12 The use of pioglitazone, a thiazolidinedione (TZD), may increase the risk of bladder cancer in patients with type 2 diabetes. In this study, we assessed the risk of bladder cancer associated with the use of TZDs and between pioglitazone and rosiglitazone, an alternative TZD. Methods We conducted a retrospective cohort study of patients with type […]

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