Longitudinal changes in insulin sensitivity and beta cell function between women with and without a history of gestational diabetes mellitus

Aims/hypothesis The aim of the study was to compare longitudinal changes in insulin sensitivity (SI) and beta cell function between women with and without a history of gestational diabetes mellitus (GDM). Methods The prospective follow-up cohort included 235 parous non-diabetic Mexican–American women, 93 with and 142 without a history of GDM. The participants underwent dual-energy […]

Racial Comparisons of Diabetes Care and Intermediate Outcomes in a Patient-Centered Medical Home

Diabetes Care: November 19, 2013 OBJECTIVE To assess racial differences in diabetes processes and intermediate outcomes of care in an internal medicine, patient-centered medical home (PCMH) group practice. RESEARCH DESIGN AND METHODS We conducted a retrospective cohort study of 1,457 adults with diabetes receiving care from 89 medical providers within a PCMH-designated, academic practice between July 1, 2009 […]

Disparities in Diabetes: The Nexus of Race, Poverty, and Place

American Journal of Public Health: Apr 24, 2013 Objectives. We sought to determine the role of neighborhood poverty and racial composition on race disparities in diabetes prevalence. Methods. We used data from the 1999–2004 National Health and Nutrition Examination Survey and 2000 US Census to estimate the impact of individual race and poverty and neighborhood racial composition and […]

Concerns About Professional Chinese Medicine Among Chinese Immigrants With Type 2 Diabetes

Diabetes Spectrum: November 2013   Purpose. The purpose of this study was to examine Chinese Americans’ beliefs regarding professional Chinese medicine (CM) in diabetes management. Previous research showed substantial variations in Chinese Americans’ beliefs about the role of professional CM, such as acupuncture and herbal medicine, in diabetes management. To provide culturally sensitive care, health care providers […]

American Indians & Alaska Natives: You Have the Power to Prevent Diabetes; The Research Says So!

Ndep: 10/23 “Diabetes is a major threat to our American Indian and Alaska Native communities,” says Charlene Avery, M.D., chair of the American Indian and Alaska Native Work Group for the National Diabetes Education Program. “But it doesn’t have to be. As a community, we have the power to change this by taking a few small […]

Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: a randomised trial

Springer: December 2013 Aims/hypothesis The aim of this work was to evaluate the efficacy and safety of canagliflozin vs placebo and sitagliptin in patients with type 2 diabetes who were being treated with background metformin. Methods This randomised, double-blind, four-arm, parallel-group, Phase 3 study was conducted at 169 centres in 22 countries between April 2010 and […]

Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass

Springer: December 2013 Aims/hypothesis Roux-en-Y gastric bypass (RYGB) improves glycaemic control in part by increasing postprandial insulin secretion through exaggerated glucagon-like peptide (GLP)-1 release. However, it is unknown whether islet cell responsiveness to i.v. glucose, non-glucose (arginine) and incretin hormones, including GLP-1, is altered. Methods Eleven severely obese glucose-tolerant individuals underwent three hyperglycaemic clamps with arginine […]

Start of insulin therapy in patients with type 2 diabetes mellitus promotes the influx of macrophages into subcutaneous adipose tissue

Springer: December 2013 Aims/hypothesis Insulin therapy in patients with type 2 diabetes mellitus is accompanied by weight gain characterised by an increase in abdominal fat mass. The expansion of adipose tissue mass is generally paralleled by profound morphological and inflammatory changes. We hypothesised that the insulin-associated increase in fat mass would also result in changes […]

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

Nejm: 11/9/13 Although inhibitors of the renin–angiotensin–aldosterone system can slow the progression of diabetic kidney disease, the residual risk is high. Whether nuclear 1 factor (erythroid-derived 2)–related factor 2 activators further reduce this risk is unknown. Full Text of Background… METHODS We randomly assigned 2185 patients with type 2 diabetes mellitus and stage 4 chronic kidney […]

Impact of Conversation Map™ Education Tools Versus Regular Care on Diabetes-Related Knowledge of People With Type 2 Diabetes: A Randomized, Controlled Study

Diabetes Spectrum: November 2013 Objective. This study compared the effectiveness of Conversation Map™ (CM) education tools versus regular care of adults with type 2 diabetes. Methods. Participants from Spain and Germany were randomized to either four CM education sessions or regular care. Data were collected at baseline (visit 1), immediately post-education (visit 2), and 6 months later (visit 3). […]

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