Association of Glycation Gap With Mortality and Vascular Complications in Diabetes

OBJECTIVE The “glycation gap” (G-gap), an essentially unproven concept, is an empiric measure of disagreement between HbA_1c and fructosamine, the two indirect estimates of glycemic control. Its association with demographic features and key clinical outcomes in individuals with diabetes is uncertain.

RESEARCH DESIGN AND METHODS The G-gap was calculated as the difference between measured HbA_1c and a fructosamine-derived standardized predicted HbA_1c in 3,182 individuals with diabetes. The G-gap’s associations with demographics and clinical outcomes (retinopathy, nephropathy, macrovascular disease, and mortality) were determined. Read more