Body Composition is Main Determinant for the Difference in Type 2 Diabetes Pathophysiology between Japanese and Caucasians

Minority Diabetes Reports Wednesday, October 23rd, 2013

Diabetes Care October 15, 2013

Objective This cross-sectional clinical study compared the pathophysiology of type 2 diabetes in Japanese and Caucasians and investigated the role of demographic, genetic, and lifestyle-related risk factors for insulin resistance and beta-cell response.

Research Design and Methods A total of 120 Japanese and 150 Caucasians were enrolled to obtain comparable distributions of high/low BMI values across glucose tolerance states (normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes), which were assessed by oral glucose tolerance tests. BMI in the two cohorts was distributed around the two regional cut-off values for obesity. Read More

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