Clinical Trial News
Thursday, July 17th, 2014
Diabetes Care July 10, 2014 OBJECTIVE The determinants of insulin-associated weight gain in type 2 diabetes mellitus (T2DM) are partly unknown. Therefore, we conducted a prospective study to identify predictors of insulin-associated weight gain. RESEARCH DESIGN AND METHODS In patients with T2DM, we assessed physical activity by accelerometry and diabetes-related distress measured by questionnaires before and 6 and […]
Clinical Trial News
Thursday, July 17th, 2014
Diabetes Care July 10, 2014 OBJECTIVE The presence of large subcutaneous adipocytes in obesity has been proposed to be linked with insulin resistance and type 2 diabetes through the “adipose tissue expandability” hypothesis, which holds that large adipocytes have a limited capacity for expansion, forcing lipids to be stored in nonadipose ectopic depots (skeletal muscle, liver), where […]
Clinical Trial News
Thursday, July 17th, 2014
The Lancet: 3 July 2014 Background Many patients with advanced type 2 diabetes do not meet their glycated haemoglobin targets and randomised controlled studies comparing the efficacy of pump treatment and multiple daily injections for lowering glucose in insulin-treated patients have yielded inconclusive results. We aimed to resolve this uncertainty with a randomised controlled trial […]
Clinical Trial News, News
Thursday, July 17th, 2014
The Lancet: 16 June 2014 Background Metformin is the recommended first-line pharmacotherapy for patients with type 2 diabetes. There is no consensus on the optimum second-line pharmacotherapy. We compared the efficacy and safety of the sodium glucose cotransporter 2 inhibitor empagliflozin and the sulfonylurea glimepiride as add-on to metformin in patients with type 2 diabetes. Methods […]
Clinical Trial News
Thursday, July 17th, 2014
The Lancet: 02 June 2014 Background Diabetes and non-diabetic dysglycaemia are risk factors for accelerated cognitive decline. In this planned substudy of the Outcome Reduction with Initial Glargine Intervention (ORIGIN) trial, we assessed whether normalising glucose with insulin glargine or administering omega-3 fatty acids in this population may slow this process or affect the development […]
Clinical Trial News
Wednesday, July 16th, 2014
Springer: August 2014 Abstract Aims/hypothesis The aim of the study was to compare the effect of six (A6 regimen) vs two meals a day, breakfast and lunch (B2 regimen), on body weight, hepatic fat content (HFC), insulin resistance and beta cell function. Methods In a randomised, open, crossover, single-centre study (conducted in Prague, Czech Republic), […]
Clinical Trial News
Wednesday, July 16th, 2014
Springer: July 2014 For many years, the randomised controlled clinical trial (RCT) has been the gold standard for evaluating the efficacy, tolerability and safety of drugs. The modern framework for RCTs was developed in the mid-20th century through the leadership of the UK Medical Research Council and the US National Institutes of Health in collaboration with […]
Clinical Trial News
Wednesday, July 16th, 2014
Springer: July 2014 Abstract Aims/hypothesis The aim of this study was to investigate whether small doses of intense exercise before each main meal (‘exercise snacks’) would result in better blood glucose control than a single bout of prolonged, continuous, moderate-intensity exercise in individuals with insulin resistance. Methods Nine individuals completed three exercise interventions in randomised […]
Clinical Trial News
Wednesday, July 16th, 2014
Springer: July 2014 Aims/hypothesis The aim of this study was to assess whether or not a theory-based behaviour change intervention delivered by trained and quality-assured lifestyle facilitators can achieve and maintain improvements in physical activity, dietary change, medication adherence and smoking cessation in people with recently diagnosed type 2 diabetes. Methods An explanatory randomised controlled […]
Clinical Trial News
Wednesday, July 16th, 2014
Cambridge: 4/30/14 Abstract The present meta-analysis of randomised controlled trials (RCT) aimed to investigate the effect of oat intake on glycaemic control and insulin sensitivity. A literature search was carried out in PubMed, ScienceDirect Online and The Cochrane Library (up to October 2013) for RCT that assessed the effect of oat intake on glucose control […]
