Differing Effects of Metformin on Glycemic Control by Race-Ethnicity

Minority Diabetes Reports, Minority Diabetes Reports Saturday, July 5th, 2014
The Journal of Clinical Endocrinology & Metabolism: June 12, 2014
Abstract
Context:

Metformin is considered first-line treatment for type 2 diabetes mellitus. However, little is known about its effects in African American individuals.

Objective:

The objective of the study was to assess whether metformin’s effect on glycemic control differs by race-ethnicity

Design:

Electronic health records were used to identify adults who had a diagnosis of diabetes, two or more fills of metformin, and two or more glycated hemoglobin (HbA1c) measurements. Pharmacy claims were used to estimate metformin exposure based on fill frequency and dose dispensed. Regression analyses modeled the relationship between metformin exposure and HbA1c levels. Analyses were stratified by race-ethnicity and baseline HbA1c values. Read More

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