Effect of a cooked meat meal on serum creatinine and estimated glomerular filtration rate in diabetes related kidney disease

Diabetes Care: September 23, 2013

OBJECTIVE Fasting is not routinely recommended for renal function tests, despite the known effects of cooked meat on creatinine. We therefore studied variation in creatinine and estimate glomerular filtration rate (eGFR) following a standardised cooked meat meal in 80 subjects: healthy volunteers, diabetes patients with chronic kidney disease (CKD) stages 1 & 2, 3A, 3B and 4 (n=16/group).

RESEARCH DESIGN AND METHODS The interventions were a standardised cooked meat and a non-meat meal, each providing approximately 54g protein, together with 250 mls of water, on separate days. Fasting and post-prandial blood samples at 1, 2, and 4 hours were drawn for creatinine measurement using kinetic alkaline picrate assay on an Olympus AU640 analyser. The modified 4-variable MDRD equation traceable to isotope dilution mass spectrometry creatinine was used to calculate eGFR. Read More