Genetic variation in MTNR1B is associated with gestational diabetes mellitus and contributes only to the absolute level of beta cell compensation in Mexican Americans

Minority Diabetes Reports Wednesday, July 16th, 2014

Springer: July 2014

Abstract

Aims/hypothesis

MTNR1B is a type 2 diabetes susceptibility locus associated with cross-sectional measures of insulin secretion. We hypothesised that variation in MTNR1B contributes to the absolute level of a diabetes-related trait, temporal rate of change in that trait, or both.

Methods

We tested rs10830963 for association with cross-sectional diabetes-related traits in up to 1,383 individuals or with rate of change in the same phenotypes over a 3–5 year follow-up in up to 374 individuals from the family-based BetaGene study of Mexican Americans. Read More

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