Relationship between diabetes risk and admixture in postmenopausal African-American and Hispanic-American women
Minority Diabetes Reports Tuesday, February 28th, 2012Springer Link: L. Qi, R. Nassir, R. Kosoy, L. Garcia, J. D. Curb, L. Tinker, B. V. Howard, J. Robbins and M. F. Seldin. DOI: 10.1007/s00125-012-2486-4. Feb. 10, 2012.
Abstract
Aims/hypothesis
Type 2 diabetes is more prevalent in African-Americans (AFAs) and Hispanic-Americans (HAs) than in European-Americans. We assessed whether continental admixture was correlated with diabetes risk in these high-risk groups.
Methods
We estimated the proportion of sub-Saharan African (AFR), Amerindian (AMI) and European admixture using 92 ancestry-informative marker genotypes in 16,476 AFA and HA women from the Women’s Health Initiative. Cox regression models were used to examine the association between admixture and diabetes risk, with and without accounting for socioeconomic status (SES) and adiposity measurements.
Results
AFR admixture was significantly associated with diabetes risk in AFA women when adjusting for entry age, neighbourhood SES and BMI or waist/hip ratio (WHR) (all p < 0.0001). In HA women, AMI admixture had significant associations with diabetes risk that remained significant after adjustment for SES and BMI (all p < 0.0005). In both AFAs and HAs, SES showed significant negative associations while BMI or WHR had significant positive associations with diabetes risk, with and without adjustment for genetic admixture. Read More
