Sex hormone binding globulin and sex steroids among premenopausal women in the Diabetes Prevention Program

JCEM: May 24, 2013

Context It is unknown whether intensive lifestyle modification (ILS) or metformin change sex steroids among premenopausal women without a history of polycystic ovarian syndrome (PCOS).

Objectives To examine one-year intervention impact upon sex steroids (estradiol, testosterone, dehydroepiandrosterone, and androstenedione [A4]) and sex hormone binding globulin (SHBG) and differences by race/ethnicity

Participants A subgroup of Diabetes Prevention Program (DPP) participants who were premenopausal, not using estrogen, without a history of PCOS or irregular menses, and who reported non-Hispanic white (NHW), Hispanic, or African-American race/ethnicity (n=301).  Read more

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