Racial/Ethnic Differences in the Prevalence of Proteinuric and Nonproteinuric Diabetic Kidney Disease

ADA: 12/13/12 OBJECTIVE To examine racial/ethnic differences in the prevalence of diabetic kidney disease (DKD), with and without proteinuria, in an outpatient health care organization. RESEARCH DESIGN AND METHODS We examined electronic health records for 15,683 persons of non-Hispanic white (NHW), Asian (Asian Indian, Chinese, and Filipino), Hispanic, and non-Hispanic black (NHB) race/ethnicity with type 2 diabetes […]

Admixture Mapping of Coronary Artery Calcified Plaque in African Americans with Type 2 Diabetes

AHA: December 11, 2012, Background—The presence and severity of coronary artery calcified plaque (CAC) differs markedly between individuals of African and European descent, suggesting that admixture mapping (AM) may be informative for identifying genetic variants associated with subclinical cardiovascular disease (CVD). Methods and Results—AM of CAC was performed in 1,040 unrelated African Americans with type […]

Mexico–United States Migration and the Prevalence of Obesity: A Transnational Perspective

JAMA: Dec 10/24, 2012 Country of birth and length of stay in the United States have proven to be strong predictors of obesity among Mexican Americans,1 suggesting the US environment may be distinctively “obesogenic.”2 For example, a 12-oz bottle of American-made Coca-Cola has 240 calories with 65 g of sugar, whereas Mexican-made Coca-Cola has 150 calories per […]

Statins and Risk of Diabetes

ADA: December 17, 2012 An analysis of electronic medical records to evaluate possible bias due to differential survival OBJECTIVE Two meta-analyses of randomized trials of statins found increased risk of type 2 diabetes. One possible explanation is bias due to differential survival when patients who are at higher risk of diabetes survive longer under statin treatment. […]

Efficacy and Safety of Sitagliptin Versus Glipizide in Patients With Type 2 Diabetes and Moderate-to-Severe Chronic Renal Insufficiency

ADA: December 17, 2012 OBJECTIVE Patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease have an increased risk of micro- and macrovascular disease, but limited options for antihyperglycemic therapy. We compared the efficacy and safety of sitagliptin with glipizide in patients with T2DM and moderate-to-severe chronic renal insufficiency and inadequate glycemic control. RESEARCH DESIGN […]

Diabetic Retinopathy, its Progression and Incident Cardiovascular Events in the ACCORD Trial

ADA: December 13, 2012 OBJECTIVE Both the presence of diabetic retinopathy and its severity are significantly associated with future cardiovascular (CV) events. Whether its progression is also linked to incident CV outcomes hasn’t been assessed. RESEARCH DESIGN AND METHODS The relationship between retinopathy, its 4-year progression, and CV outcomes (CV death or nonfatal myocardial infarction or stroke) […]

Acute Macrovascular Dysfunction in Patients With Type 2 Diabetes Mellitus Induced by Ingestion of Advanced Glycated Betalactoglobulins

ADA: December 13, 2012 OBJECTIVES Recent evidence indicates that heat-enhanced food advanced glycation end products (AGEs) adversely affect vascular function. The aim of this study was to examine the acute effects of an oral load of heat-treated, AGE-modified β-lactoglobulins (AGE-BLG) compared with heat-treated, nonglycated BLG (C-BLG) on vascular function in patients with type 2 diabetes mellitus (T2DM). […]

Effects of Metformin Versus Glipizide on Cardiovascular Outcomes in Patients With Type 2 Diabetes and Coronary Artery Disease

ADA: December 10, 2012 OBJECTIVE The two major classes of antidiabetic drugs, sulfonylureas and metformin, may differentially affect macrovascular complications and mortality in diabetic patients. We compared the long-term effects of glipizide and metformin on the major cardiovascular events in type 2 diabetic patients who had a history of coronary artery disease (CAD). RESEARCH DESIGN AND […]

Impaired Fasting Plasma Glucose and Type 2 Diabetes Are Related to the Risk of Out-of-Hospital Sudden Cardiac Death and All-Cause Mortality

ADA: December 17, 2012 OBJECTIVE The aim of the study was to determine whether impaired fasting plasma glucose (FPG) and type 2 diabetes may be risk factors for sudden cardiac death (SCD). RESEARCH DESIGN AND METHODS This prospective study was based on 2,641 middle-aged men 42–60 years of age at baseline. Impaired FPG level (≥5.6 mmol/L) among […]

Health Care Costs in People With Diabetes and Their Association With Glycemic Control and Kidney Function

ADA: 12/13/12 OBJECTIVE To determine the association between laboratory-derived measures of glycemic control (HbA1c) and the presence of renal complications (measured by proteinuria and estimated glomerular filtration rate [eGFR]) with the 5-year costs of caring for people with diabetes. RESEARCH DESIGN AND METHODS We estimated the cumulative 5-year cost of caring for people with diabetes using a […]

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