Minority Diabetes Reports
Thursday, May 30th, 2013
Diabetes Care June 1, 2013 OBJECTIVE Human blood glucose levels have likely evolved toward their current point of stability over hundreds of thousands of years. The robust population stability of this trait is called canalization. It has been represented by a hyperbolic function of two variables: insulin sensitivity and insulin response. Environmental changes due to global migration […]
Minority Diabetes Reports
Thursday, May 30th, 2013
Red Orbit: May 24, 2013 Ethnic background plays a surprisingly large role in how diabetes develops on a cellular level, according to two new studies led by researchers at the Stanford University School of Medicine. The researchers reanalyzed disease data to demonstrate that the physiological pathways to diabetes vary between Africa and East Asia and […]
Minority Diabetes Reports
Thursday, May 30th, 2013
JCEM: May 24, 2013 Context It is unknown whether intensive lifestyle modification (ILS) or metformin change sex steroids among premenopausal women without a history of polycystic ovarian syndrome (PCOS). Objectives To examine one-year intervention impact upon sex steroids (estradiol, testosterone, dehydroepiandrosterone, and androstenedione [A4]) and sex hormone binding globulin (SHBG) and differences by race/ethnicity Participants A subgroup of Diabetes […]
Minority Diabetes Reports
Thursday, May 30th, 2013
StrokeAHA: April 25, 2013 Background and Purpose—We previously reported increased incidence of ischemic stroke among both blacks and whites with diabetes mellitus, especially in those aged <55 years. With rising prevalence of diabetes mellitus in the past decade, we revisit the impact of diabetes mellitus on stroke incidence in the same population (≈1.3 million) 5 and […]
Minority Diabetes Reports
Thursday, May 30th, 2013
DiabetesADA: February 8, 2013 Advanced glycation end products (AGEs) and their receptors are strongly implicated in the development of diabetes complications. When stimulated by AGEs, the receptors for AGEs (RAGEs) induce inflammation and are thought to fuel disease progression. Soluble circulating RAGE (sRAGE) may counteract the detrimental effects of RAGE. We measured sRAGE in stored plasma […]
Clinical Trials
Thursday, May 30th, 2013
Diabetes Care: June 1, 2013 Recent reports demonstrate an incredibly worrisome finding, specifically that there is an increased frequency of type 2 diabetes in youth. Given the importance of the problem of type 2 diabetes in youth and the need to effectively disseminate the information, our editorial team has elected to feature the TODAY study in […]
Clinical Trials
Thursday, May 30th, 2013
Diabetes Care May 28, 2013 OBJECTIVE The 200 units/mL formulation of insulin degludec (IDeg 200 units/mL) contains equal units of insulin in half the volume compared with the 100 units/mL formulation. We compared the efficacy and safety of IDeg 200 units/mL once daily with 100 units/mL insulin glargine (IGlar) in insulin-naïve subjects with type 2 diabetes (T2DM) […]
Clinical Trials
Thursday, May 30th, 2013
Diabetes Care May 22, 2013 OBJECTIVE To compare efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled with metformin. RESEARCH DESIGN AND METHODS Adults with diabetes inadequately controlled (HbA1c 7–10%) with metformin were randomized to lixisenatide 20 μg once daily (n = 318) or exenatide 10 μg twice daily (n = 316) in […]
Clinical Trials
Thursday, May 30th, 2013
Diabetes Care: January 15, 2013 OBJECTIVE To assess the feasibility of using a disposable, self-administered, capillary blood sampling oral glucose tolerance test (OGTT) device in a community setting. RESEARCH DESIGN AND METHODS Eighteen healthy and 12 type 2 diabetic volunteers underwent six 75-g OGTTs using a prototype device in the following three settings: unaided at home (twice); unaided […]
Clinical Trials
Thursday, May 30th, 2013
Diabetes Care: December 28, 2012 OBJECTIVE To assess the clinical efficacy of nutritional amounts of grape polyphenols (PPs) in counteracting the metabolic alterations of high-fructose diet, including oxidative stress and insulin resistance (IR), in healthy volunteers with high metabolic risk. RESEARCH DESIGN AND METHODS Thirty-eight healthy overweight/obese first-degree relatives of type 2 diabetic patients (18 men and 20 […]
