Lower “Awake and Fed Thermogenesis” Predicts Future Weight Gain in Subjects with Abdominal Adiposity

ADA: 8/23/13 Awake and fed thermogenesis (AFT) is the energy expenditure (EE) of the non-active fed condition above the minimum metabolic requirement during sleep, and is composed of the thermic effect of food and the cost of being awake. AFT was estimated from whole room 24-h EE measures in 509 healthy subjects (368 Native Americans and 141 […]

Mexican American Trial of Community Health Workers: A Randomized Controlled Trial of a Community Health Worker Intervention for Mexican Americans With Type 2 Diabetes Mellitus

American Journal of Public Health: 8/15/13 Objectives. We assessed whether community health workers (CHWs) could improve glycemic control among Mexican Americans with diabetes. Methods. We recruited 144 Mexican Americans with type 2 diabetes between January 2006 and September 2008 into the single-blinded, randomized controlled Mexican American Trial of Community Health Workers (MATCH) and followed them for 2 years. […]

Sociocultural and Socioeconomic Influences on Type 2 Diabetes Risk in Overweight/Obese African-American and Latino-American Children and Adolescents

Hindawi: 5/13/13 Purpose. It is unclear whether sociocultural and socioeconomic factors are directly linked to type 2 diabetes risk in overweight/obese ethnic minority children and adolescents. This study examines the relationships between sociocultural orientation, household social position, and type 2 diabetes risk in overweight/obese African-American () and Latino-American () children and adolescents.Methods. Sociocultural orientation was assessed […]

Modulation by Dietary Fat and Carbohydrate of IRS1 Association With Type 2 Diabetes Traits in Two Populations of Different Ancestries

ADA: 4/17/13 OBJECTIVE Insulin receptor substrate 1 (IRS1) is central to insulin signaling pathways. This study aimed to examine the association of IRS1 variants with insulin resistance (IR) and related phenotypes, as well as potential modification by diet. RESEARCH DESIGN AND METHODS Two IRS1 variants (rs7578326 and rs2943641) identified by genome-wide association studies as related to type 2 diabetes were tested for […]

‘The Human Trial’: Filming Diabetes Cure Research in Action

Diabetesmine: August 27, 2013 Sometimes, all the latest headlines on steps towards curing diabetes can seem like a broken record — just researchers crying wolf about how big and bad their science projects are. Fellow type 1 Lisa Hepner in California gets that, and as someone living with diabetes for more than 20 years, she often […]

Metreleptin improves blood glucose in patients with insulin receptor mutations

JCEM: 8/22/13 Context: Rabson-Mendenhall syndrome (RMS) is caused by mutations of the insulin receptor, and results in extreme insulin resistance and dysglycemia. Hyperglycemia in RMS is very difficult to treat, and patients are at risk for early morbidity and mortality from complications of diabetes. Objective: To study one year effects of recombinant human methionyl leptin (metreleptin) in five […]

The People Behind the Numbers

Forecast.diabetes: 8/14/13 Before the landmark Diabetes Control and Complications Trial (DCCT), Carolyn Wolf was not a huge fan of diabetes dos and don’ts. “At that time, they gave us only so many calories. I could be compliant with injections, but staying to a particular calorie allotment was difficult,” she says. “I felt like I was in […]

Sucralose Affects Glycemic and Hormonal Responses to an Oral Glucose Load

ADA: 4/30/13 OBJECTIVE Nonnutritive sweeteners (NNS), such as sucralose, have been reported to have metabolic effects in animal models. However, the relevance of these findings to human subjects is not clear. We evaluated the acute effects of sucralose ingestion on the metabolic response to an oral glucose load in obese subjects. RESEARCH DESIGN AND METHODS Seventeen obese […]

Very Low–Calorie Diet Mimics the Early Beneficial Effect of Roux-en-Y Gastric Bypass on Insulin Sensitivity and β-Cell Function in Type 2 Diabetic Patients

ADA: 4/22/13 Marked improvement in glycemic control occurs in patients with type 2 diabetes mellitus shortly after Roux-en-Y gastric bypass surgery (RYGB) and before there is major weight loss. The objective of this study was to determine whether the magnitude of this change is primarily due to caloric restriction or is unique to the surgical […]

The Health Insurance Marketplace & People with Diabetes

Starting on October 1, 2013, individuals and families have a new opportunity to buy health insurance through a Health Insurance Marketplace (Marketplace) available in every state. Coverage purchased in the Marketplace will be effective as early as January 1, 2014. Starting in 2014, all new health insurance plans, whether sold inside or outside the Marketplace, […]

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