Association Between Intensification of Metformin Treatment With Insulin vs Sulfonylureas and Cardiovascular Events and All-Cause Mortality Among Patients With Diabetes

JAMA: June 11, 2014 Importance  Preferred second-line medication for diabetes treatment after metformin failure remains uncertain. Objective  To compare time to acute myocardial infarction (AMI), stroke, or death in a cohort of metformin initiators who added insulin or a sulfonylurea. Design, Setting, and Participants  Retrospective cohort constructed with national Veterans Health Administration, Medicare, and National Death Index databases. The study […]

Insulin Therapy for Type 2 Diabetes Mellitus

JAMA: June 11, 2014 Importance  The incidence and prevalence of type 2 diabetes mellitus are increasing. Objective  To review currently available insulin therapy, as well as evidence on the use, application, initiation, and intensification of insulin in the outpatient setting. Evidence Review  Data sources included PubMed for trials and investigations in type 2 diabetes examining insulin use from January 1998 to […]

More than 29 million Americans have diabetes; 1 in 4 doesn’t know

CDC: Tuesday, June 10, 2014 Prevention efforts crucial to combat serious health risks People with diabetes often use a blood glucose monitoring device to help them maintain healthy glucose levels. More than 29 million people in the United States have diabetes, up from the previous estimate of 26 million in 2010, according to a report […]

Diabetes as risk factor for incident coronary heart disease in women compared with men: a systematic review and meta-analysis of 64 cohorts including 858,507 individuals and 28,203 coronary events

Springer: May 2014 Aims/hypothesis A previous pooled analysis suggested that women with diabetes are at substantially increased risk of fatal CHD compared with affected men. Additional findings from several larger and more contemporary studies have since been published on the sex-specific associations between diabetes and incident CHD. We performed an updated systematic review with meta-analysis to […]

New Diabetes Nutrition Therapy Recommendations: What You Need to Know

Diabetes Spectrum May 2014 The American Diabetes Association (ADA) has long recognized the integral role of nutrition therapy in overall diabetes management and recommends that each person with diabetes receive an individualized eating plan that has been developed in collaboration with his or her health care provider (HCP).1 To ensure that members of the health care team […]

Association of a Low-Frequency Variant in HNF1A With Type 2 Diabetes in a Latino Population

JAMA: June 11, 2014 Importance  Latino populations have one of the highest prevalences of type 2 diabetes worldwide. Objectives  To investigate the association between rare protein-coding genetic variants and prevalence of type 2 diabetes in a large Latino population and to explore potential molecular and physiological mechanisms for the observed relationships. Design, Setting, and Participants  Whole-exome sequencing was performed on DNA […]

Depression and Risk Perceptions in Older African Americans With Diabetes

Diabetes Spectrum: May 2014 Objective. The purpose of this study is to describe the impact of depression on perceptions of risks to health, diabetes self-management practices, and glycemic control in older African Americans with type 2 diabetes. Methods. The authors analyzed data on depression, risk perceptions, diabetes self-management, and A1C in African Americans with type 2 diabetes. T-tests, χ2, […]

Depressive Symptoms, Antidepressant Use, and the Incidence of Diabetes in the Black Women’s Health Study

Diabetes Care May 1, 2014 OBJECTIVE To assess the relationship of depressive symptoms and use of antidepressants with incident type 2 diabetes in prospective data from a large cohort of U.S. African American women. RESEARCH DESIGN AND METHODS The Black Women’s Health Study (BWHS) is an ongoing prospective cohort study. We followed 35,898 women from 1999 through 2011 […]

Individual Mindfulness-Based Cognitive Therapy (MBCT) and Cognitive Behavior Therapy (CBT) for Treating Depressive Symptoms in Patients With Diabetes: Results of a Randomized Controlled Trial

Diabetes Care June 4, 2014 OBJECTIVE Depression is a common comorbidity of diabetes, undesirably affecting patients’ physical and mental functioning. Psychological interventions are effective treatments for depression in the general population as well as in patients with a chronic disease. The aim of this study was to assess the efficacy of individual mindfulness-based cognitive therapy (MBCT) and […]

Advancing Basal Insulin Replacement in Type 2 Diabetes Inadequately Controlled With Insulin Glargine Plus Oral Agents: A Comparison of Adding Albiglutide, a Weekly GLP-1 Receptor Agonist, Versus Thrice-Daily Prandial Insulin Lispro

Diabetes Care: June 4, 2014 OBJECTIVE GLP-1 receptor agonists may provide an alternative to prandial insulin for advancing basal insulin therapy. Harmony 6 was a randomized, open-label, active-controlled trial testing once-weekly albiglutide vs thrice-daily prandial insulin lispro as an add-on to titrated once-daily insulin glargine. RESEARCH DESIGN AND METHODS Patients taking basal insulin (with or without oral agents) […]

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