Depression and Adherence to Lifestyle Changes in Type 2 Diabetes A Systematic Review

The Diabetes Educator” June 17, 2014 Abstract Purpose Depression affects millions of people worldwide and is prevalent among those with diabetes. The purpose of this review was to synthesize recent research on depression and adherence to dietary and physical activity recommendations in persons with type 2 diabetes (T2DM). Methods This systematic review is a subanalysis of an NIH-funded […]

Higher potency statins and the risk of new diabetes: multicentre, observational study of administrative databases

BMJ: d 29 May 2014 Abstract Objective To evaluate the incremental increase in new onset diabetes from higher potency statins compared with lower potency statins when used for secondary prevention. Design Eight population based cohort studies and a meta-analysis. Setting Six Canadian provinces and two international databases from the UK and US. Participants 136 966 patients aged ≥40 years newly treated […]

Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond

Diabetologia/ Springer: 8/1/14 During the past 7 years, genome-wide association studies have shed light on the contribution of common genomic variants to the genetic architecture of type 2 diabetes, obesity and related intermediate phenotypes. The discoveries have firmly established more than 175 genomic loci associated with these phenotypes. Despite the tight correlation between type 2 diabetes and […]

Contributors to Mortality in High-Risk Diabetic Patients in the Diabetes Heart Study

Diabetes Care: July 2, 2014 OBJECTIVE Not all individuals with type 2 diabetes and high coronary artery calcified plaque (CAC) experience the same risk for adverse outcomes. This study examined a subset of high-risk individuals based on CAC >1,000 mg (using a total mass score) and evaluated whether differences in a range of modifiable cardiovascular disease (CVD) […]

Breast-feeding and maternal risk of type 2 diabetes: a prospective study and meta-analysis

Springer/Diabetologia: July 2014 Aims/hypothesis We aimed to examine the association between breast-feeding and maternal risk of type 2 diabetes and to investigate whether this association is mediated by anthropometric and biochemical factors. Methods A case–cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study between 1994 and 2005 including 1,262 childbearing women […]

Effect of Patients’ Risks and Preferences on Health Gains With Plasma Glucose Level Lowering in Type 2 Diabetes Mellitus

JAMA: 6/30/14 Importance  Type 2 diabetes mellitus is common, and treatment to correct blood glucose levels is standard. However, treatment burden starts years before treatment benefits accrue. Because guidelines often ignore treatment burden, many patients with diabetes may be overtreated. Objective  To examine how treatment burden affects the benefits of intensive vs moderate glycemic control in patients with […]

Starting Insulin Treatment for Diabetes

JAMA Patient Page | June 11, 2014 In people with type 2 diabetes, the body does not use insulin properly and, over time, cannot make enough insulin. Some people with type 2 diabetes will need treatment with insulin. THE IMPORTANCE OF INSULIN IN TREATING TYPE 2 DIABETES Diabetes is a condition that causes high blood sugars. Diabetes affects long-term […]

The performance of diabetes risk prediction models in new populations: the role of ethnicity of the development cohort

Springer: July 2014 Abstract It is believed that diabetes risk scores need to be ethnic specific. However, this prerequisite has not been tested. We examined the performance of several risk models, developed in various populations, in a Europid and a South Asian population. The performance of 14 published risk prediction models were tested in two prospective […]

Genetic variation in MTNR1B is associated with gestational diabetes mellitus and contributes only to the absolute level of beta cell compensation in Mexican Americans

Springer: July 2014 Abstract Aims/hypothesis MTNR1B is a type 2 diabetes susceptibility locus associated with cross-sectional measures of insulin secretion. We hypothesised that variation in MTNR1B contributes to the absolute level of a diabetes-related trait, temporal rate of change in that trait, or both. Methods We tested rs10830963 for association with cross-sectional diabetes-related traits in up to 1,383 […]

The Role of Vitamin D in the Health of Hispanic Adults With Diabetes

Ingentaconnec: 6/1/14 Abstract: The highest prevalence of low vitamin D levels are among Hispanics and non-Hispanic Blacks. Evidence suggests that low vitamin D levels may contribute to increased risk for diabetes and its complications. Hispanics are at greater risk for vitamin D deficiency. To address the relationship between vitamin D, diabetes, and Hispanics, this research […]

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