The performance of diabetes risk prediction models in new populations: the role of ethnicity of the development cohort

Springer: July 2014 Abstract It is believed that diabetes risk scores need to be ethnic specific. However, this prerequisite has not been tested. We examined the performance of several risk models, developed in various populations, in a Europid and a South Asian population. The performance of 14 published risk prediction models were tested in two prospective […]

Genetic variation in MTNR1B is associated with gestational diabetes mellitus and contributes only to the absolute level of beta cell compensation in Mexican Americans

Springer: July 2014 Abstract Aims/hypothesis MTNR1B is a type 2 diabetes susceptibility locus associated with cross-sectional measures of insulin secretion. We hypothesised that variation in MTNR1B contributes to the absolute level of a diabetes-related trait, temporal rate of change in that trait, or both. Methods We tested rs10830963 for association with cross-sectional diabetes-related traits in up to 1,383 […]

The Role of Vitamin D in the Health of Hispanic Adults With Diabetes

Ingentaconnec: 6/1/14 Abstract: The highest prevalence of low vitamin D levels are among Hispanics and non-Hispanic Blacks. Evidence suggests that low vitamin D levels may contribute to increased risk for diabetes and its complications. Hispanics are at greater risk for vitamin D deficiency. To address the relationship between vitamin D, diabetes, and Hispanics, this research […]

Ethnic-Specific Obesity Cutoffs for Diabetes Risk: Cross-sectional Study of 490,288 UK Biobank Participants

Diabetes Care June 29, 2014 OBJECTIVE To compare the relationship between adiposity and prevalent diabetes across ethnic groups in the UK Biobank cohort and to derive ethnic-specific obesity cutoffs that equate to those developed on white populations in terms of diabetes prevalence. RESEARCH DESIGN AND METHODS UK Biobank recruited 502,682 U.K. residents aged 40–69 years. We used baseline […]

Food-Insecure Dietary Patterns Are Associated With Poor Longitudinal Glycemic Control in Diabetes: Results From the Boston Puerto Rican Health Study

Diabetes Care June 26, 2014 OBJECTIVE To determine whether dietary patterns associated with food insecurity are associated with poor longitudinal glycemic control. RESEARCH DESIGN AND METHODS In a prospective, population-based, longitudinal cohort study, we ascertained food security (Food Security Survey Module), dietary pattern (Healthy Eating Index 2005 [HEI 2005]), and hemoglobin A1c (HbA1c) in Puerto Rican adults aged 45–75 […]

Self-care and Subjectivity among Mexican Diabetes Patients in the United Statesa

Wiley: 19 JUN 2014 Type 2 diabetes is considered a public health crisis, particularly among people of Mexican descent in the United States. Clinical approaches to diabetes management increasingly emphasize self-care, which places responsibility for illness on individuals and mandates self-regulation. Using narrative and free-list data from a two-phase study of low-income first- and second-generation […]

Differing Effects of Metformin on Glycemic Control by Race-Ethnicity

The Journal of Clinical Endocrinology & Metabolism: June 12, 2014 Abstract Context: Metformin is considered first-line treatment for type 2 diabetes mellitus. However, little is known about its effects in African American individuals. Objective: The objective of the study was to assess whether metformin’s effect on glycemic control differs by race-ethnicity Design: Electronic health records were […]

Association of a Low-Frequency Variant in HNF1A With Type 2 Diabetes in a Latino Population

JAMA: June 11, 2014 Importance  Latino populations have one of the highest prevalences of type 2 diabetes worldwide. Objectives  To investigate the association between rare protein-coding genetic variants and prevalence of type 2 diabetes in a large Latino population and to explore potential molecular and physiological mechanisms for the observed relationships. Design, Setting, and Participants  Whole-exome sequencing was performed on DNA […]

Depression and Risk Perceptions in Older African Americans With Diabetes

Diabetes Spectrum: May 2014 Objective. The purpose of this study is to describe the impact of depression on perceptions of risks to health, diabetes self-management practices, and glycemic control in older African Americans with type 2 diabetes. Methods. The authors analyzed data on depression, risk perceptions, diabetes self-management, and A1C in African Americans with type 2 diabetes. T-tests, χ2, […]

Depressive Symptoms, Antidepressant Use, and the Incidence of Diabetes in the Black Women’s Health Study

Diabetes Care May 1, 2014 OBJECTIVE To assess the relationship of depressive symptoms and use of antidepressants with incident type 2 diabetes in prospective data from a large cohort of U.S. African American women. RESEARCH DESIGN AND METHODS The Black Women’s Health Study (BWHS) is an ongoing prospective cohort study. We followed 35,898 women from 1999 through 2011 […]

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